Obesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia. Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure. Bone marrow-derived multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSC) are envisioned as a therapeutic tool not only for cardiovascular diseases but also for other degenerative conditions. Our aim was to evaluate whether the intravenous administration of MSC modifies cardiac dysfunction in obese mice. To this end, C57BL/6 mice were fed a regular (normal) or high-fat diet (obese). Obese animals received the vehicle (obese), a single dose (obese + 1x MSC) or...
Background: Obesity and metabolic syndrome lead to the development of metabolic heart disease (MHD) ...
INTRODUCTION: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into ...
Abstract Background Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy....
Background: Obesity is a complex disease involving the accumulation of body fat that can inflict a s...
White adipose tissue (WAT) is distributed in several depots with distinct metabolic and inflammatory...
Abstract Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of o...
Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complication...
Mesenchymal stem cells offer a promising approach to the treatment of myocardial infarction and prev...
Mesenchymal cells have been shown to improve contractile function in rodents following myocardial in...
Background/Aim: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Rationale: Bone marrow (BM)–derived mesenchymal stem cells (MSCs) hold great promise for cardiovascu...
BACKGROUND/AIM: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Background/Aim: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Mesenchymal stem cells (MSCs) are multipotent cells with trans-differentiation capacity. High glucos...
INTRODUCTION: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into ...
Background: Obesity and metabolic syndrome lead to the development of metabolic heart disease (MHD) ...
INTRODUCTION: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into ...
Abstract Background Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy....
Background: Obesity is a complex disease involving the accumulation of body fat that can inflict a s...
White adipose tissue (WAT) is distributed in several depots with distinct metabolic and inflammatory...
Abstract Adipose-derived mesenchymal stem cells (ASCs) are a promising option for the treatment of o...
Abstract Background: Diabetes mellitus is a severe chronic disease leading to systemic complication...
Mesenchymal stem cells offer a promising approach to the treatment of myocardial infarction and prev...
Mesenchymal cells have been shown to improve contractile function in rodents following myocardial in...
Background/Aim: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Rationale: Bone marrow (BM)–derived mesenchymal stem cells (MSCs) hold great promise for cardiovascu...
BACKGROUND/AIM: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Background/Aim: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syn...
Mesenchymal stem cells (MSCs) are multipotent cells with trans-differentiation capacity. High glucos...
INTRODUCTION: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into ...
Background: Obesity and metabolic syndrome lead to the development of metabolic heart disease (MHD) ...
INTRODUCTION: Human mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into ...
Abstract Background Cardiac steatosis is an early yet overlooked feature of diabetic cardiomyopathy....