ABSTRACT Major health challenges as the increasing number of cases of infections by antibiotic multiresistant microorganisms and cases of Alzheimer's disease have led to searching new control drugs. The present study aims to verify a new way of obtaining bioactive extracts from filamentous fungi with potential antimicrobial and acetylcholinesterase inhibitory activities, using epigenetic modulation to promote the expression of genes commonly silenced. For such finality, five filamentous fungal species (Talaromyces funiculosus, Talaromyces islandicus, Talaromyces minioluteus, Talaromyces pinophilus, Penicillium janthinellum) were grown or not with DNA methyltransferases inhibitors (procainamide or hydralazine) and/or a histone deacetylase in...
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Department of Pharmac...
A manipulação seletiva de alvos epigenéticos usando pequenas moléculas inibidoras das enzimas histon...
Effective fungal growth inhibitors are important to drive the development of antifungal compound. In...
Fungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed ...
For decades, fungi have been the main source for the discovery of novel antimicrobial drugs. Recent ...
Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing ...
Fungi are among the most prolific producers of secondary metabolites, many of which have huge utilit...
Fungi usually contain gene clusters that are silent or cryptic under normal laboratory culture condi...
Aspergillus spp. are environmental filamentous fungi that cause a wide spectrum of infections in hum...
To indicate the importance of fungal enzyme inhibitors (FEI) it is only required to mention penicill...
The filamentous fungus Aspergillus clavatus is known to produce a variety of secondary metabolites (...
Fungi are talented organisms able to produce several natural products with a wide range of structura...
The use of epigenetic modifiers, such as histone deacetylase inhibitors and DNA methyltransferase in...
Fungi are talented organisms able to produce several natural products with a wide range of structura...
Natural product search is an enduring revitalization upon the exploration of a huge already exotic p...
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Department of Pharmac...
A manipulação seletiva de alvos epigenéticos usando pequenas moléculas inibidoras das enzimas histon...
Effective fungal growth inhibitors are important to drive the development of antifungal compound. In...
Fungal metabolites with antioxidant and acetylcholinesterase inhibitory activities can be developed ...
For decades, fungi have been the main source for the discovery of novel antimicrobial drugs. Recent ...
Alzheimer's disease is a neurodegenerative illness, so far without cure, that affects an increasing ...
Fungi are among the most prolific producers of secondary metabolites, many of which have huge utilit...
Fungi usually contain gene clusters that are silent or cryptic under normal laboratory culture condi...
Aspergillus spp. are environmental filamentous fungi that cause a wide spectrum of infections in hum...
To indicate the importance of fungal enzyme inhibitors (FEI) it is only required to mention penicill...
The filamentous fungus Aspergillus clavatus is known to produce a variety of secondary metabolites (...
Fungi are talented organisms able to produce several natural products with a wide range of structura...
The use of epigenetic modifiers, such as histone deacetylase inhibitors and DNA methyltransferase in...
Fungi are talented organisms able to produce several natural products with a wide range of structura...
Natural product search is an enduring revitalization upon the exploration of a huge already exotic p...
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department Department of Pharmac...
A manipulação seletiva de alvos epigenéticos usando pequenas moléculas inibidoras das enzimas histon...
Effective fungal growth inhibitors are important to drive the development of antifungal compound. In...