Background/Aims: Hypertrophic ligamentum flavum (LF) is a major cause of lumbar spinal stenosis. Our previous work showed that high levels of lysophosphatidic acid (LPA) expression are positively correlated with LF hypertrophy. This study aimed to further unveil how LPA regulates LF hypertrophy Methods: We studied LPAR1 expression in human LF cells using PCR and western blotting. Cell viability cell cycle, apoptosis rate and molecular mechanisms were assayed in LPAR1 knockdown or overexpression LF cells. LF hypertrophy and the molecular mechanism was confirmed in human samples and in in vivo studies. Results: The expression of LPA and its receptor LPAR1 is significantly higher in tissues or cells harvested from hypertrophic LF compared to h...
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G pro...
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that is involved in diverse bio...
Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, activates G protein-coupl...
<b><i>Background/Aims:</i></b> Hypertrophic ligamentum flavum (LF) is a major cause of lumbar spinal...
Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is the prototype member of a f...
International audienceLysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six...
Abstract Background Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G pro...
International audienceLysphosphatidic acid (LPA) is a major natural bioactive lipid mediator whose b...
Background/Aims: Narrowing of the lumbar spinal canal is a condition called lumbar spinal stenosis (...
The bioactive lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have d...
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signal...
Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most...
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on...
Lysophosphatidic acid (LPA) is a small signaling phospholipid that mediates diverse functions inclu...
Lysophosphatidic acid acyltransferase (LPAAT-β) is a phosphatidic acid (PA) generating enzyme that p...
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G pro...
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that is involved in diverse bio...
Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, activates G protein-coupl...
<b><i>Background/Aims:</i></b> Hypertrophic ligamentum flavum (LF) is a major cause of lumbar spinal...
Lysophosphatidic acid (LPA, 1-radyl-2-hydroxy-sn-glycero-3-phosphate) is the prototype member of a f...
International audienceLysophosphatidic acid (LPA) is a natural bioactive lipid that acts through six...
Abstract Background Lysophosphatidic acid (LPA) is a lipid mediator that acts through specific G pro...
International audienceLysphosphatidic acid (LPA) is a major natural bioactive lipid mediator whose b...
Background/Aims: Narrowing of the lumbar spinal canal is a condition called lumbar spinal stenosis (...
The bioactive lysophospholipids lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have d...
Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular signal...
Lysophosphatidic acid (LPA) is the simplest signalling lipid eliciting pleiotropic actions upon most...
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on...
Lysophosphatidic acid (LPA) is a small signaling phospholipid that mediates diverse functions inclu...
Lysophosphatidic acid acyltransferase (LPAAT-β) is a phosphatidic acid (PA) generating enzyme that p...
Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G pro...
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid mediator that is involved in diverse bio...
Lysophosphatidic acid (LPA), a naturally occurring bioactive phospholipid, activates G protein-coupl...