The role of single nucleotide polymorphisms of NFATC genes in the development of left ventricular hypertrophy in primary arterial hypertensive adolescents

The aim of the study was to determine the possibility of association of the single nucleotide polymorphisms (SNP) of NFATC1 and NFATC4 genes with the development of concentric hypertrophy of the left ventricle (LVH) in adolescents aged 16-18 with newly diagnosed primary hypertension (AH). Material and methods. The study included 74 adolescents aged 16-18 years (50 boys and 24 girls) who for the first time in the course of preventive medical examination were identified as primary hypertensive carriers. According to the echocardioscopy (Echo-CS) the concentric hypertrophy of the left ventricle was shown in 32 (43%) of adolescents. Other 42 (57%) young people with AH were identified as a control group because their Echo-CS and еlectrocardiography (ECG) data were within the age limits. At the next stage of the study for all the patients the genotyping by a standard PCR method in a real time was performed using samples of total DNA isolated from the whole venous blood. Results. As shown by the results of genotyping and statistical analysis SNP association with LVH was detected in relation to rs2229309 of the NFATC4 gene and not confirmed for SNP (rs7240256, rs11665469, rs754505) of the NFATC1 gene. Statistically significant differences of incidence (p