Nattokinase (NK), which has been identified as a potent fibrinolytic protease, has remarkable potential in treatment of thrombolysis, and even has the ability to ameliorate chronic vein thrombosis. To reduce the hemorrhagic risk from an intravenous injection of NK, nattokinase-tauroursodeoxycholate (NK-TUDCA) complex was prepared at different pH values and with different ratios of NK and TUDCA. When assessing survival time, survival state, tail injury, and the body weight of mice, it was found that the NK-TUDCA complex (NK: 10 kIU/ml; TUDCA: 10 mg/ml; pH 5.0) had a lower toxicity when administered at an NK dosage of 130 kIU/kg in the acute toxicity test and 13 kIU/kg in the repeated low-dose challenge. From the results of the in vitro throm...
Nattokinase is a novel fibrinolytic enzyme that is considered to be a promising agent for thrombosis...
Coronary artery disease (CAD) is a condition caused by the buildup of plaque in the coronary artery....
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current scena...
Abstract:1)Bacillus subtilis natto producing high level of a fibrinolytic enzyme was selected and Ul...
Cardiovascular diseases (CVDs) are the leading causes of premature death and disability in people ar...
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands o...
© The Author(s) 2018. Cardiovascular disease (CVD) is the leading cause of death in the world and ou...
Nattokinase is a fibrinolytic enzyme identified and isolated in 1987 from a specific Japanese food c...
Nattokinase is a potent fibrinolytic enzyme. The composition of the medium for the production of nat...
Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic disorder diagnosed by thrombocytopen...
Current state-of-the-art acute ischemic stroke clinical trials are designed to study neuroprotectant...
One of the main disadvantages of current t-PA thrombolytic treatment is the increased bleeding risk....
AbstractLumbrokinase (LK) is a group of serine proteases with strong fibrinolytic and thrombolytic a...
Nattokinase is a novel fibrinolytic enzyme, which is homologous to Subtilisin Carlsberg. In this pap...
Thrombosis has threatened human health in past decades. Bacillus nattokinase is a potential low-cost...
Nattokinase is a novel fibrinolytic enzyme that is considered to be a promising agent for thrombosis...
Coronary artery disease (CAD) is a condition caused by the buildup of plaque in the coronary artery....
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current scena...
Abstract:1)Bacillus subtilis natto producing high level of a fibrinolytic enzyme was selected and Ul...
Cardiovascular diseases (CVDs) are the leading causes of premature death and disability in people ar...
Natto, a fermented soybean product, has been consumed as a traditional food in Japan for thousands o...
© The Author(s) 2018. Cardiovascular disease (CVD) is the leading cause of death in the world and ou...
Nattokinase is a fibrinolytic enzyme identified and isolated in 1987 from a specific Japanese food c...
Nattokinase is a potent fibrinolytic enzyme. The composition of the medium for the production of nat...
Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic disorder diagnosed by thrombocytopen...
Current state-of-the-art acute ischemic stroke clinical trials are designed to study neuroprotectant...
One of the main disadvantages of current t-PA thrombolytic treatment is the increased bleeding risk....
AbstractLumbrokinase (LK) is a group of serine proteases with strong fibrinolytic and thrombolytic a...
Nattokinase is a novel fibrinolytic enzyme, which is homologous to Subtilisin Carlsberg. In this pap...
Thrombosis has threatened human health in past decades. Bacillus nattokinase is a potential low-cost...
Nattokinase is a novel fibrinolytic enzyme that is considered to be a promising agent for thrombosis...
Coronary artery disease (CAD) is a condition caused by the buildup of plaque in the coronary artery....
Enzyme therapies are attracting significant attention as thrombolytic drugs during the current scena...