An algorithmic approach for the treatment of severe uncontrolled asthma
- Eleftherios Zervas
- Konstantinos Samitas
- Andriana I. Papaioannou
- Petros Bakakos
- Stelios Loukides
- Mina Gaga
DOIAbstract
A small subgroup of patients with asthma suffers from severe disease that is either partially controlled or uncontrolled despite intensive, guideline-based treatment. These patients have significantly impaired quality of life and although they constitute <5% of all asthma patients, they are responsible for more than half of asthma-related healthcare costs. Here, we review a definition for severe asthma and present all therapeutic options currently available for these severe asthma patients. Moreover, we suggest a specific algorithmic treatment approach for the management of severe, difficult-to-treat asthma based on specific phenotype characteristics and biomarkers. The diagnosis and management of severe asthma requires specialised experien...
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