Background/Aims: The main pathogenic mechanism of diabetes is a decrease in the number of islet beta cells or a decline in their function. Recent studies have shown that pancreatic long noncoding RNAs (lncRNAs) have a high degree of tissue specificity and may be involved in the maintenance of islet cells function and the development of diabetes. The aim of this study was to investigate the molecular regulatory mechanism of mouse maternal expressed gene 3 (Meg3) in insulin biosynthesis in pancreatic islets. Methods: Chromatin immunoprecipitation–quantitative polymerase chain reaction (qPCR) and RNA immunoprecipitation–qPCR were used to investigate the molecular mechanism of lncRNA Meg3 in insulin biosynthesis by regulating v-Maf musculoapone...
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of whic...
In pancreatic beta cells, insulin biosynthesis and secretion is tightly regulated by a network of tr...
SummaryA significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several ...
Objective: There is strong evidence for an involvement of different classes of non-coding RNAs, incl...
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involv...
OBJECTIVE: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involv...
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by inadequate insulin s...
SummaryType 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the in...
AIMS/HYPOTHESIS: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immun...
Increasing evidence indicates that long noncoding RNAs (lncRNAs) have crucial roles in various biolo...
Background/Aims: The islet is an important endocrine organ to secrete insulin to regulate the metabo...
Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in var...
OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marke...
The discovery that most mammalian genome sequences are transcribed to ribonucleic acids (RNA) has re...
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of whic...
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of whic...
In pancreatic beta cells, insulin biosynthesis and secretion is tightly regulated by a network of tr...
SummaryA significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several ...
Objective: There is strong evidence for an involvement of different classes of non-coding RNAs, incl...
Objective: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involv...
OBJECTIVE: Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involv...
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by inadequate insulin s...
SummaryType 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the in...
AIMS/HYPOTHESIS: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immun...
Increasing evidence indicates that long noncoding RNAs (lncRNAs) have crucial roles in various biolo...
Background/Aims: The islet is an important endocrine organ to secrete insulin to regulate the metabo...
Objective: Histone deacetylases are epigenetic regulators known to control gene transcription in var...
OBJECTIVE: Pancreatic islets of perinatal mice lacking the transcription factor Rfx3 exhibit a marke...
The discovery that most mammalian genome sequences are transcribed to ribonucleic acids (RNA) has re...
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of whic...
A significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several of whic...
In pancreatic beta cells, insulin biosynthesis and secretion is tightly regulated by a network of tr...
SummaryA significant portion of the genome is transcribed as long noncoding RNAs (lncRNAs), several ...