Research of Antidepressive Activity of Di-Na-Salt Of 2-(Pyridine-4-Iltio)Succinic AciD

Досліджено антидепресивну активність нетоксичної сполуки – динатрієвої солі 2-(піридин-4-ілтіо)бурш- тинової кислоти в тестах Порсолта та «Підвішування мишей за хвіст». Встановлено, що ця речовина проявляє значний антидепресивний ефект, який наближується до еталону порівняння «Велаксину», і може слугувати основою для створення нових нетоксичних лікарських засобів.Nowadays the number of patients suffering from depressive disturbance which need a medical correction was recently enlargedin the world. In this work antidepressive action of untoxic substance – di-Na-salt of 2-(pyridine-4- iltio)succinic acid was studied in Porsolt’s test and «Hanging of mice by a tail». In the Porsolt’s testdi-Na-salt of 2-(pyridine-4-iltio)succinic acidin a dose of 120 mg/kg caused reliable decrease of passive swimming time in relation to control which comes nearer to a comparison preparation indicator – a known strong antidepressant «Velaksin». The tendency to its augmentation was observedin the analysis of the 1-st lag time. The results received in the «Hanging of mice by a tail» test indicate even more appreciable antidepressive activity of di-Na-salt of 2-(pyridine-4-iltio)succinic acid. At introduction of substance in more effective dose (120 mg/kg) appreciable decrease of immobility time was observed in relation to control that is almost near to a standard indicator – «Velaksin». Thus, di-Na-salt of 2-(pyridine-4-iltio)succinic acid can serve for creation of new untoxical pharmaceutical preparationson its basis