How MYC reprograms metabolism in primary tumors remains poorly understood. Using integrated gene expression and metabolite profiling, we identify six pathways that are coordinately deregulated in primary MYC-driven liver tumors: glutathione metabolism; glycine, serine, and threonine metabolism; aminoacylt-RNA biosynthesis; cysteine and methionine metabolism; ABC transporters; and mineral absorption. We then focus our attention on glutathione (GSH) and glutathione disulfide (GSSG), as they are markedly decreased in MYC-driven tumors. We find that fewer glutamine-derived carbons are incorporated into GSH in tumor tissue relative to non-tumor tissue. Expression of GCLC, the rate-limiting enzyme of GSH synthesis, is attenuated by the MYC-induce...
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. Howev...
Studies from many laboratories document that the MYC oncogene produces a pleiotropic transcription f...
AbstractAltered cellular metabolism is a fundamental adaptation of cancer during rapid proliferation...
Reprogramming of Glutamate Metabolism and Redox Homeostasis in De Novo MYC-Driven Liver TumorsBritta...
SummaryThe altered metabolism of tumors has been considered a target for anticancer therapy. However...
Plasticity of cancer metabolism can be a major obstacle to efficient targeting of tumour-specific me...
The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patie...
Summaryc-Myc is known to promote glutamine usage by upregulating glutaminase (GLS), which converts g...
One of the hallmarks of cancer is the ability to generate and withstand unusual levels of oxidative ...
Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the tra...
One of the major oncogenes dysregulated in breast cancer is MYC. MYC is a master regulator transcrip...
Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, ...
Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: g...
Summary: The liver plays central roles in coordinating different metabolic processes, such as the ca...
Metabolic reprogramming is a key feature of tumorigenesis that is controlled by oncogenes. Enhanced ...
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. Howev...
Studies from many laboratories document that the MYC oncogene produces a pleiotropic transcription f...
AbstractAltered cellular metabolism is a fundamental adaptation of cancer during rapid proliferation...
Reprogramming of Glutamate Metabolism and Redox Homeostasis in De Novo MYC-Driven Liver TumorsBritta...
SummaryThe altered metabolism of tumors has been considered a target for anticancer therapy. However...
Plasticity of cancer metabolism can be a major obstacle to efficient targeting of tumour-specific me...
The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patie...
Summaryc-Myc is known to promote glutamine usage by upregulating glutaminase (GLS), which converts g...
One of the hallmarks of cancer is the ability to generate and withstand unusual levels of oxidative ...
Objective: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the tra...
One of the major oncogenes dysregulated in breast cancer is MYC. MYC is a master regulator transcrip...
Myc transcriptionally regulates genes involved in processes such as cell proliferation, metabolism, ...
Mammalian cells fuel their growth and proliferation through the catabolism of two main substrates: g...
Summary: The liver plays central roles in coordinating different metabolic processes, such as the ca...
Metabolic reprogramming is a key feature of tumorigenesis that is controlled by oncogenes. Enhanced ...
Tumors driven by activation of the transcription factor MYC generally show oncogene addiction. Howev...
Studies from many laboratories document that the MYC oncogene produces a pleiotropic transcription f...
AbstractAltered cellular metabolism is a fundamental adaptation of cancer during rapid proliferation...