Thienopyridine skeleton has been reported as having interesting biological activity, namely antitumor [1] and antiangiogenic [2] activities. Herein we describe the synthesis of di(hetero)arylethers 1a-f and di(hetero)arylamines 2a-f functionalizing the 7-position of the thieno[3,2-b]pyridine in good to high yields, using copper (C-O) or palladium (C-N) catalyzed couplings, like presented below. The growth inhibitory activity of the di(hetero)arylethers 1a-f and di(hetero)arylamines 2a-f was evaluated against five human tumor cell lines (breast- MCF-7, non-small cell lung- NCI-H460, colon- HCT15- hepatocellular- HepG2 and cervical- HeLa carcinomes), using the sulforhodamine B assay. Furthermore, the hepatotoxicity of compounds was studied...
New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functio...
Our previous work has described a library of thioxanthones designed to have dual activity as P-glyco...
3-Methyl-6-phenyl-2-thioxo-2,3-dihydro-thieno[3,2-d]pyrimidin-4(1H)-one (2), on treatment with phosp...
New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functio...
Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylth...
Thienopyridine skeleton has been reported as havi ng inte resting biological activity, namely antit...
Several novel methyl 7-[(hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates were synthesized by P...
Hepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and...
The methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by some of us, was ...
Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portu...
Hepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and...
Several series of compounds that include the thienopyridine scaffold have been reported as inhibit...
Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year w...
Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupli...
Tese de Doutoramento em Ciências - Especialidade em QuímicaThe synthesis of novel 1-aryl-3-[3- or 4-...
New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functio...
Our previous work has described a library of thioxanthones designed to have dual activity as P-glyco...
3-Methyl-6-phenyl-2-thioxo-2,3-dihydro-thieno[3,2-d]pyrimidin-4(1H)-one (2), on treatment with phosp...
New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functio...
Synthesis and evaluation of the antitumor potential of new aminated or methoxylated di(hetero)arylth...
Thienopyridine skeleton has been reported as havi ng inte resting biological activity, namely antit...
Several novel methyl 7-[(hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates were synthesized by P...
Hepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and...
The methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate, recently reported by some of us, was ...
Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portu...
Hepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and...
Several series of compounds that include the thienopyridine scaffold have been reported as inhibit...
Hepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year w...
Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupli...
Tese de Doutoramento em Ciências - Especialidade em QuímicaThe synthesis of novel 1-aryl-3-[3- or 4-...
New fluorinated and methoxylated di(hetero)arylethers and di(hetero)arylamines were prepared functio...
Our previous work has described a library of thioxanthones designed to have dual activity as P-glyco...
3-Methyl-6-phenyl-2-thioxo-2,3-dihydro-thieno[3,2-d]pyrimidin-4(1H)-one (2), on treatment with phosp...