1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays

Queiroz, Maria João R. P.
Peixoto, Daniela
Soares, Pedro
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Costa, Raquel
Soares, Raquel

January 2012

Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portu...

Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies

Peixoto, Daniela
Calhelha, Ricardo C.
Dias, Sofia
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.

January 2011

When over expressed or mutated, protein tyrosine kinases become potent oncoproteins that cause dereg...

Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)

Perspicace, Enrico
Jouan-Hureaux, Valerie
Ragno, Rino
Ballante, Flavio
Sartini, Stefania
La Motta, Concettina
Da Settimo, Federico
Chen, Binbin
Kirsch, Gilbert
Schneider, Serge
Faivre, Beatrice
Hesse, Stephanie

January 2013

Driven by a multidisciplinary approach combination (Structure-Based (SB) Three-Dimensional Quantitat...

Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors

Queiroz, Maria João R.P.
Peixoto, Daniela
Calhelha, Ricardo C.
Abreu, Rui M.V.
Froufe, Hugo J.C.
Ferreira, Isabel C.F.R.
Costa, Raquel
Soares, Raquel

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) is a class of tyrosine kinase receptors, exp...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

Queiroz, Maria João R.P.
Peixoto, Daniela
Soares, Pedro
Abreu, Rui M.V.
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.
Costa, Raquel
Soares, Raquel

January 2012

A number of thienopyrimidines derivatives have shown potent vascular endothelial growth factor recep...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays

Peixoto, Daniela
Calhelha, Ricardo C.
Soares, Pedro
Abreu, Rui M. V.
Froufe, Hugo J. C.
Ferreira, Isabel C. F. R.
Costa, Raquel
Soares, Raquel

November 2012

Acknowledgments:To the FCT–Portugal for financial support through the PTNMR network. To FCT and COMP...

1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: synthesis, biological evaluation, and molecular modelling studies

Soares, Pedro
Costa, Raquel
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Peixoto, Daniela
Ferreira, Isabel C. F. R.
Abreu, Rui M. V.
Soares, Raquel
Queiroz, Maria João R. P.

January 2013

The vascular endothelial growth factor receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved i...

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

Machado, Vera A.
Peixoto, D.
Costa, R.
Froufe, H. J. C.
Calhelha, Ricardo C.
Abreu, R. M. V
Ferreira, Isabel C. F. R.
Soares, R.
Queiroz, Maria João R. P.

January 2015

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthi...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies

Soares, Pedro
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Borges, Fernanda
Queiroz, Maria João R.P.

January 2011

Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling ...

1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2

Soares, Pedro
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Borges, Fernanda
Queiroz, Maria João R.P.

January 2011

The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research i...

Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors

Peixoto, Daniela
Queiroz, Maria João R. P.
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in ...

Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors

Peixoto, Daniela
Queiroz, Maria João R.P.
Abreu, Rui M.V.
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in ...

Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2

Campos, Joana F.
Begouin, Agathe
Peixoto, Daniela
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.

January 2013

Angiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor p...

Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors

Machado, Vera A.
Peixoto, Daniela
Costa, Raquel
Calhelha, Ricardo C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Soares, Raquel
Queiroz, Maria João R.P.

January 2014

The vascular endothelial growth factor receptor 2 (VEGFR-2) is a tyrosine kinase receptor, expressed...

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

Machado, Vera A.
Peixoto, Daniela
Costa, Raquel
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Soares, Raquel
Queiroz, Maria João R.P.

January 2015

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthi...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays

Queiroz, Maria João R. P.
Peixoto, Daniela
Soares, Pedro
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Costa, Raquel
Soares, Raquel

January 2012

Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portu...

Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies

Peixoto, Daniela
Calhelha, Ricardo C.
Dias, Sofia
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.

January 2011

When over expressed or mutated, protein tyrosine kinases become potent oncoproteins that cause dereg...

Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)

Perspicace, Enrico
Jouan-Hureaux, Valerie
Ragno, Rino
Ballante, Flavio
Sartini, Stefania
La Motta, Concettina
Da Settimo, Federico
Chen, Binbin
Kirsch, Gilbert
Schneider, Serge
Faivre, Beatrice
Hesse, Stephanie

January 2013

Driven by a multidisciplinary approach combination (Structure-Based (SB) Three-Dimensional Quantitat...

Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors

Queiroz, Maria João R.P.
Peixoto, Daniela
Calhelha, Ricardo C.
Abreu, Rui M.V.
Froufe, Hugo J.C.
Ferreira, Isabel C.F.R.
Costa, Raquel
Soares, Raquel

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) is a class of tyrosine kinase receptors, exp...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays

Queiroz, Maria João R.P.
Peixoto, Daniela
Soares, Pedro
Abreu, Rui M.V.
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.
Costa, Raquel
Soares, Raquel

January 2012

A number of thienopyrimidines derivatives have shown potent vascular endothelial growth factor recep...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays

Peixoto, Daniela
Calhelha, Ricardo C.
Soares, Pedro
Abreu, Rui M. V.
Froufe, Hugo J. C.
Ferreira, Isabel C. F. R.
Costa, Raquel
Soares, Raquel

November 2012

Acknowledgments:To the FCT–Portugal for financial support through the PTNMR network. To FCT and COMP...

1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: synthesis, biological evaluation, and molecular modelling studies

Soares, Pedro
Costa, Raquel
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Peixoto, Daniela
Ferreira, Isabel C. F. R.
Abreu, Rui M. V.
Soares, Raquel
Queiroz, Maria João R. P.

January 2013

The vascular endothelial growth factor receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved i...

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-Aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

Machado, Vera A.
Peixoto, D.
Costa, R.
Froufe, H. J. C.
Calhelha, Ricardo C.
Abreu, R. M. V
Ferreira, Isabel C. F. R.
Soares, R.
Queiroz, Maria João R. P.

January 2015

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthi...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies

Soares, Pedro
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Borges, Fernanda
Queiroz, Maria João R.P.

January 2011

Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling ...

1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2

Soares, Pedro
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Borges, Fernanda
Queiroz, Maria João R.P.

January 2011

The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research i...

Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors

Peixoto, Daniela
Queiroz, Maria João R. P.
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in ...

Synthesis of novel 1-aryl-3-[2,3- or 4-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors

Peixoto, Daniela
Queiroz, Maria João R.P.
Abreu, Rui M.V.
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Ferreira, Isabel C.F.R.

January 2012

Vascular endothelial growth factor receptor 2 (VEGFR2) tyrosine kinase is involved in cancer and in ...

Synthesis of new N-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors the tyrosine kinase domain of VEGFR2

Campos, Joana F.
Begouin, Agathe
Peixoto, Daniela
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.

January 2013

Angiogenesis, the growth of new vessels from preexisting vasculature, is a critical step in tumor p...

Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors

Machado, Vera A.
Peixoto, Daniela
Costa, Raquel
Calhelha, Ricardo C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Soares, Raquel
Queiroz, Maria João R.P.

January 2014

The vascular endothelial growth factor receptor 2 (VEGFR-2) is a tyrosine kinase receptor, expressed...

Synthesis, antiangiogenesis evaluation and molecular docking studies of 1-aryl-3-[(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas: Discovery of a new substitution pattern for type II VEGFR-2 Tyr kinase inhibitors

Machado, Vera A.
Peixoto, Daniela
Costa, Raquel
Froufe, Hugo J.C.
Calhelha, Ricardo C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Soares, Raquel
Queiroz, Maria João R.P.

January 2015

The synthesis and biological evaluation of novel 1-aryl-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylthi...

1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays

Queiroz, Maria João R. P.
Peixoto, Daniela
Soares, Pedro
Abreu, Rui M. V.
Froufe, Hugo J. C.
Calhelha, Ricardo C.
Ferreira, Isabel C. F. R.
Costa, Raquel
Soares, Raquel

January 2012

Foundation for the Science and Technology (FCT–Portugal) for financial support through the NMR Portu...

Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies

Peixoto, Daniela
Calhelha, Ricardo C.
Dias, Sofia
Froufe, Hugo J.C.
Abreu, Rui M.V.
Ferreira, Isabel C.F.R.
Queiroz, Maria João R.P.

January 2011

When over expressed or mutated, protein tyrosine kinases become potent oncoproteins that cause dereg...

Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)

Perspicace, Enrico
Jouan-Hureaux, Valerie
Ragno, Rino
Ballante, Flavio
Sartini, Stefania
La Motta, Concettina
Da Settimo, Federico
Chen, Binbin
Kirsch, Gilbert
Schneider, Serge
Faivre, Beatrice
Hesse, Stephanie

January 2013

Driven by a multidisciplinary approach combination (Structure-Based (SB) Three-Dimensional Quantitat...

1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays

Abstract

Extracted data

1-Aryl-3-[ 4-( thieno[3,2-d]pyrimidin-4-yloxy )phenyl]ureas as VEG FR2 inhibitors: synthesis, docking enzymatic and cellular assays

Abstract

Extracted data

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