Modelling dissolution of sparingly soluble powders

The present work deals with the simulation of the dissolution process of polydisperse powders. Three different size fractions of Ibuprofen were used to develop a model which assumes a diffusion layer thickness proportional to the particle diameter, up to a critical value, beyond which it is considered constant. The application of the resultant integrated equations to each size class of the primary particle size distribution leads to an almost perfect agreement between simulated and experimental dissolution profiles