BACKGROUND: In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) correlates with cytotoxic effector activity. For cells bearing the Vgamma2Vdelta2 T cell receptor, isoprenoid pyrophosphate stimulation leads to uniform activation and proliferation, but only a fraction of cells express CD56 and display potent cytotoxic activity against tumor cells. Our goal was to show whether CD56 expression was regulated stochastically, similar to conventional activation antigens, or whether CD56 defined a lineage of cells committed to the cytotoxic phenotype. RESULTS: Tracking individual cell clones defined by their Vgamma2 chain CDR3 region sequences, we found that CD56 was expressed on precursor cytotoxic T cells already present...
Human plasmacytoid and myeloid dendritic cells (DCs), when appropriately stimulated, can express the...
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool f...
of IL-4 by the tumour cells supported the view that the lym-phoma was not of NK cell origin (Emoto 2...
Background: In lymphocyte subsets, expression of CD56 ( neural cell adhesion molecule-1) correlates ...
Abstract Background In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) corr...
Background: In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) correlates w...
A subset of human T lymphocytes expresses the natural killer (NK) cell-associated receptor CD56 and ...
Cytokine-induced killer (CIK) cells are in-vitro-expanded T lymphocytes that represent a heterogeneo...
A particularly interesting marker to identify anti-tumor immune cells is the neural cell adhesion mo...
The CD56 antigen is expressed on several deadly malignancies currently lacking long-term efficacious...
Recent data suggest that human effector CD8+ T cells express a distinct CD27-CD45RAhigh (CD57+CD28-C...
In the human hematopoietic system, CD56 is considered as a classical surface marker of natural kille...
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that in...
Natural Killer (NK) cells are important innate lymphocytes for effective immune responses against in...
High levels of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) are associa...
Human plasmacytoid and myeloid dendritic cells (DCs), when appropriately stimulated, can express the...
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool f...
of IL-4 by the tumour cells supported the view that the lym-phoma was not of NK cell origin (Emoto 2...
Background: In lymphocyte subsets, expression of CD56 ( neural cell adhesion molecule-1) correlates ...
Abstract Background In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) corr...
Background: In lymphocyte subsets, expression of CD56 (neural cell adhesion molecule-1) correlates w...
A subset of human T lymphocytes expresses the natural killer (NK) cell-associated receptor CD56 and ...
Cytokine-induced killer (CIK) cells are in-vitro-expanded T lymphocytes that represent a heterogeneo...
A particularly interesting marker to identify anti-tumor immune cells is the neural cell adhesion mo...
The CD56 antigen is expressed on several deadly malignancies currently lacking long-term efficacious...
Recent data suggest that human effector CD8+ T cells express a distinct CD27-CD45RAhigh (CD57+CD28-C...
In the human hematopoietic system, CD56 is considered as a classical surface marker of natural kille...
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that in...
Natural Killer (NK) cells are important innate lymphocytes for effective immune responses against in...
High levels of tumor-infiltrating lymphocytes (TILs) in the tumor microenvironment (TME) are associa...
Human plasmacytoid and myeloid dendritic cells (DCs), when appropriately stimulated, can express the...
We examined the potential value of the natural killer (NK) cell line; NK-92, as immunotherapy tool f...
of IL-4 by the tumour cells supported the view that the lym-phoma was not of NK cell origin (Emoto 2...