Epidemiol Infect

Toxoplasma gondii is a globally distributed parasitic protozoan that infects most warm-blooded animals. We incorporated a bead coupled with recombinant SAG2A protein into our Neglected Tropical Disease (NTD) multiplex bead assay (MBA) panel and used it to determine Toxoplasma infection rates in two studies in Haiti. In a longitudinal cohort study of children aged 0-11 years, the infection rate varied with age reaching a maximum of 0\ub7131 infections/year in children aged 3 years [95% confidence interval (CI) 0\ub7065-0\ub7204]. The median time to seroconversion was estimated to be 9\ub77 years (95% CI 7\ub76- 1e). In a cross-sectional, community-wide survey of residents of all ages, we determined an overall seroprevalence of 28\ub72%. The seroprevalence age curve from the cross-sectional study also suggested that the force of infection varied with age and peaked at 0\ub7057 infections/year (95% CI 0\ub7033-0\ub7080) at age 2\ub76 years. Integration of the Toxoplasma MBA into NTD surveys may allow for better estimates of the potential burden of congenital toxoplasmosis in underserved regions.20152018-03-09T00:00:00ZCC999999/Intramural CDC HHS/United States25600668PMC584448