Environ Res

BackgroundElevated pediatric asthma morbidity has been observed in rural US communities, but the role of the ambient environment in exacerbating rural asthma is poorly understood.ObjectivesTo investigate associations between particulate matter less than 2.5 \u3bcm in diameter (PM2.5) and pediatric asthma exacerbations in an agricultural community of Washington State.MethodsSchool-aged children with asthma (n=58) were followed for up to 25 months with repeated measures of respiratory health. Asthma symptoms and quick-relief medication use were assessed biweekly through phone administered surveys (n=2023 interviews). In addition, subjects used home peak flow meters on a daily basis to measure forced expiratory volume in one second (FEV1) (n=7830 measurements). Regional PM2.5 was measured at a single air monitor located centrally in the study region. To assess relationships between PM2.5 and these outcomes we used linear regression with generalized estimating equations, adjusting for meteorological and temporal confounders. Effect modification by atopy was explored as well.ResultsAn interquartile increase (IQR) in weekly PM2.5 of 6.7 \u3bcg/m3 was associated with an increase in reported asthma symptoms. Specific symptoms including wheezing, limitation of activities, and nighttime waking displayed the strongest associations. FEV1 as a percent of predicted decreased by 0.9% (95%CI: 121.8, 0.0) for an IQR increase in PM2.5 one day prior, and by 1.4% (95%CI: 122.7, 120.2) when restricted to children with atopic asthma.ConclusionsThis study provides evidence that PM2.5 in an agricultural setting contributes to elevated asthma morbidity. Further work on identifying and mitigating sources of PM2.5 in the area is warranted.T32 HD052462/HD/NICHD NIH HHS/United StatesHD052462-01/HD/NICHD NIH HHS/United States5R21ES17906-2/ES/NIEHS NIH HHS/United StatesU54 OH007544/OH/NIOSH CDC HHS/United StatesR21 ES017906/ES/NIEHS NIH HHS/United States2016-01-01T00:00:00Z25460673PMC4425279vault:2748