Nanomaterials Versus Ambient Ultrafine Particles : An Opportunity to Exchange Toxicology Knowledge
- Stone, Vicki
- Miller, Mark R
- Clift, Martin J D
- Elder, Alison
- Mills, Nicholas L
- Møller, Peter
- Schins, Roel P F
- Vogel, Ulla
- Kreyling, Wolfgang G
- Alstrup Jensen, Keld
- Kuhlbusch, Thomas A J
- Schwarze, Per E.
- Hoet, Peter
- Pietroiusti, Antonio
- De Vizcaya-Ruiz, Andrea
- Baeza-Squiban, Armelle
- Teixeira, João Paulo
- Tran, C Lang
- Cassee, Flemming R
DOIAbstract
BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NMs, and the study of NMs provides...
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