Interactions between microtubule (MT) interacting and trafficking (MIT) domains and their binding proteins are important for the accurate progression of many cellular processes that require the AAA+ ATPase machinery. Therefore, knowledge on the structural basis of MIT domain interactions is crucial for understanding the molecular mechanisms underlying AAA+ ATPase function. Katanin is a MT-severing AAA+ ATPase that consists of p60 and p80 subunits. Although, the hexameric p60 subunit is active alone, its association with the p80 subunit greatly enhances both the MT-binding and -severing activities of katanin. However, the molecular mechanism of how the p80 subunit contributes to katanin function is currently unknown. Here, we structurally an...
Cytoskeleton is a dynamic system which contributes to a variety of cellular pro- cesses, for example...
Katanin is a heterodimeric protein that mediates ATP-dependent destabilization of microtubules in an...
Although considerable in girth (25 nm) and held together by multiple tubulin–tubulin interactions, m...
Interactions between microtubule (MT) interacting and trafficking (MIT) domains and their binding pr...
Katanin is a microtubule-severing enzyme that is crucial for many cellular processes. Katanin consis...
Summary: Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes...
AbstractMicrotubule disassembly at centrosomes is involved in mitotic spindle function. The microtub...
CAMSAP/Patronin family members regulate the organization and stability of microtubule minus ends in ...
The reorganization of microtubules in mitosis, meiosis, and development requires the microtubule-sev...
The completion of cytokinesis is crucial for mitotic cell division. Cleavage furrow ingression is fo...
<div><p>The completion of cytokinesis is crucial for mitotic cell division. Cleavage furrow ingressi...
The Katanin family of microtubule-severing enzymes is critical for remodeling microtubule-based stru...
The Katanin family of microtubule-severing enzymes is critical for remodeling microtubule-based stru...
Microtubule severing is a biochemical reaction that generates an internal break in a microtubule and...
(A) Sequence alignment of the N-terminal region, including α1, from the A.t. SPR2 C-terminal domain ...
Cytoskeleton is a dynamic system which contributes to a variety of cellular pro- cesses, for example...
Katanin is a heterodimeric protein that mediates ATP-dependent destabilization of microtubules in an...
Although considerable in girth (25 nm) and held together by multiple tubulin–tubulin interactions, m...
Interactions between microtubule (MT) interacting and trafficking (MIT) domains and their binding pr...
Katanin is a microtubule-severing enzyme that is crucial for many cellular processes. Katanin consis...
Summary: Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes...
AbstractMicrotubule disassembly at centrosomes is involved in mitotic spindle function. The microtub...
CAMSAP/Patronin family members regulate the organization and stability of microtubule minus ends in ...
The reorganization of microtubules in mitosis, meiosis, and development requires the microtubule-sev...
The completion of cytokinesis is crucial for mitotic cell division. Cleavage furrow ingression is fo...
<div><p>The completion of cytokinesis is crucial for mitotic cell division. Cleavage furrow ingressi...
The Katanin family of microtubule-severing enzymes is critical for remodeling microtubule-based stru...
The Katanin family of microtubule-severing enzymes is critical for remodeling microtubule-based stru...
Microtubule severing is a biochemical reaction that generates an internal break in a microtubule and...
(A) Sequence alignment of the N-terminal region, including α1, from the A.t. SPR2 C-terminal domain ...
Cytoskeleton is a dynamic system which contributes to a variety of cellular pro- cesses, for example...
Katanin is a heterodimeric protein that mediates ATP-dependent destabilization of microtubules in an...
Although considerable in girth (25 nm) and held together by multiple tubulin–tubulin interactions, m...