Determinants of Peripapillary and Macular Vessel Densities Measured by Optical Coherence Tomography Angiography in Normal Eyes

Purpose: The aim of this study was to evaluate the effect of subjectrelated (age, sex, and systemic hypertension and diabetes), eyerelated (refractive error, optic disc size), and technology-related (signal strength index, SSI of the scans) determinants on the peripapillary and macular vessel densities measured with optical coherence tomography angiography (OCTA) in normal eyes. Methods: In a cross-sectional study, 181 normal eyes of 107 subjects (45 men, 62 women, median age: 50 y, range: 18 to 77 y) underwent OCTA imaging. Linear mixed models were used to analyze the effect of the determinants on the peripapillary and macular vessel densities measured with OCTA. Results: It was found that age and optic disc size did not affect the vessel densities of any of the regions (P> 0.05 for all associations). En face optic disc (coefficient: 1.67, P