Endometrial scratching in women with implantation failure after a first IVF/ICSI cycle; does it lead to a higher live birth rate? The SCRaTCH study: a randomized controlled trial (NTR 5342)
- van Hoogenhuijze, N. E.
- Torrance, H. L.
- Mol, F.
- Laven, J. S. E.
- Scheenjes, E.
- Traas, M. A. F.
- Janssen, C.
- Cohlen, B.
- Teklenburg, G.
- de Bruin, J. P.
- van Oppenraaij, R.
- Maas, J. W. M.
- Moll, E.
- Fleischer, K.
- van Hooff, M. H.
- de Koning, C.
- Cantineau, A.
- Lambalk, C. B.
- Verberg, M.
- Nijs, M.
- Manger, A. P.
- van Rumste, M.
- van der Voet, L. F.
- Preys-Bosman, A.
- Visser, J.
- Brinkhuis, E.
- den Hartog, J. E.
- Sluijmer, A.
- Jansen, F. W.
- Hermes, W.
- Bandell, M. L.
- Pelinck, M. J.
- van Disseldorp, J.
- van Wely, M.
- Smeenk, J.
- Pieterse, Q. D.
- Boxmeer, J. C.
- Groenewoud, E. R.
- Eijkemans, M. J. C.
- Kasius, J. C.
- Broekmans, F. J. M.
DOIAbstract
Background: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle. Method: Multicenter randomized controlled trial in Dutch academic and non-academic hospitals. A total of 900 women will be included of whom h...
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