Purpose of review The immunomodulatory effects of ionizing radiation have long been recognized; however, so far these have not been fully exploited in clinical practice. We review the rationale to combine radiation with immune checkpoint inhibitors, which are used in standard practice. Recent findings Preclinical research suggests a synergy between radiotherapy and these immune checkpoint inhibitors. Whether or not this benefit translates into a clinical benefit is currently subject of ongoing research. Summary It is highly rational to combine radiation with immune therapy as in preclinical models and in proof of concept trials in humans it clearly can increase the antitumor immunity when given together with other immune interventions
Radiotherapy is an effective treatment modality commonly used in efforts to cure many localised canc...
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy i...
WOS: 000430063900008It has long been known that radiation destroys the tumors by killing cells. Howe...
Purpose of reviewThe immunomodulatory effects of ionizing radiation have long been recognized; howev...
Purpose of reviewThe immunomodulatory effects of ionizing radiation have long been recognized; howev...
Immune checkpoint blockade has recently emerged as an important therapeutic approach to the manageme...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
Literature experiences in cancer treatment usually deal with either targeting the tumour cell or the...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
Since the approval of anti-CTLA4 therapy (ipilimumab) for late-stage melanoma in 2011, the developme...
The revival of cancer immunotherapy has taken place with the clinical success of immune checkpoint i...
It has long been known that radiation destroys the tumorsby killing cells. However, immunotherapy is...
Radiotherapy is an effective treatment modality commonly used in efforts to cure many localised canc...
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy i...
WOS: 000430063900008It has long been known that radiation destroys the tumors by killing cells. Howe...
Purpose of reviewThe immunomodulatory effects of ionizing radiation have long been recognized; howev...
Purpose of reviewThe immunomodulatory effects of ionizing radiation have long been recognized; howev...
Immune checkpoint blockade has recently emerged as an important therapeutic approach to the manageme...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
Literature experiences in cancer treatment usually deal with either targeting the tumour cell or the...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
There is a very strong biological and pre-clinical rationale for combining radiotherapy with immune ...
Since the approval of anti-CTLA4 therapy (ipilimumab) for late-stage melanoma in 2011, the developme...
The revival of cancer immunotherapy has taken place with the clinical success of immune checkpoint i...
It has long been known that radiation destroys the tumorsby killing cells. However, immunotherapy is...
Radiotherapy is an effective treatment modality commonly used in efforts to cure many localised canc...
Recent development in radiation biology has revealed potent immunogenic properties of radiotherapy i...
WOS: 000430063900008It has long been known that radiation destroys the tumors by killing cells. Howe...