INTRODUCTION: Statins are effective at preventing cardiovascular disease, widely prescribed and their use is growing. Uncertainty persists about whether they cause symptomatic muscle adverse effects, such as pain and weakness, in the absence of statin myopathy. Discrepancies between data from observational studies, which suggest statins are associated with excess muscle symptoms, and from randomised trials, which suggest no such excess, have caused confusion. N-of-1 trials offer the opportunity to establish whether muscle symptoms during statin use are caused by statins in particular individuals. METHODS AND ANALYSIS: This series of 200 randomised, double-blinded N-of-1 trials in primary care will determine (1) the effect of statins on all ...
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease ...
Introduction: Statins remain among the most frequently prescribed drugs and constitute a cornerstone...
Objectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients w...
INTRODUCTION: Statins are effective at preventing cardiovascular disease, widely prescribed and thei...
Introduction: Statins are effective at preventing cardiovascular disease, widely prescribed and thei...
Objective: To establish the effect of statins on muscle symptoms in people who had previously report...
OBJECTIVE: To establish the effect of statins on muscle symptoms in people who had previously report...
BACKGROUND: Uncertainty persists about whether or not statins cause symptomatic muscle adverse effec...
Background: Uncertainty persists about whether or not statins cause symptomatic muscle adverse effec...
Statins are one of the most commonly prescribed drugs in the United Kingdom. There is strong evidenc...
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease ...
Introduction: Statins remain among the most frequently prescribed drugs and constitute a cornerstone...
Objectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients w...
INTRODUCTION: Statins are effective at preventing cardiovascular disease, widely prescribed and thei...
Introduction: Statins are effective at preventing cardiovascular disease, widely prescribed and thei...
Objective: To establish the effect of statins on muscle symptoms in people who had previously report...
OBJECTIVE: To establish the effect of statins on muscle symptoms in people who had previously report...
BACKGROUND: Uncertainty persists about whether or not statins cause symptomatic muscle adverse effec...
Background: Uncertainty persists about whether or not statins cause symptomatic muscle adverse effec...
Statins are one of the most commonly prescribed drugs in the United Kingdom. There is strong evidenc...
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular disease ...
Introduction: Statins remain among the most frequently prescribed drugs and constitute a cornerstone...
Objectives. Estimate the effect of atorvastatin on muscular symptom intensity in coronary patients w...