Add to ORKGBACKGROUND: Age seemed to affect the interaction between coumarins and genotype in the acenocoumarol and phenprocoumon arm of the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial. OBJECTIVES: To investigate the effect of genotype-guided dosing stratified by age and the potential factors causing a difference. PATIENTS/METHODS: Data from the acenocoumarol/phenprocoumon arm of the EU-PACT trial was used. The percentage of time below, above and in the therapeutic range (TTR) during the initial 12 weeks of therapy were compared between the genotype-guided group and the control group among younger (<75 years) and older (≥75 years) patients using independent t-test and adjust for sex, height, weight and co-medications using linea...
INTRODUCTION: A large proportion of the coumarin dose variability is explained by environmental fact...
<div><p>Appropriate dosing of coumarins is difficult to establish, due to significant inter-individu...
Abstract Background Hemorrhagic events are frequent in patients on treatment with antivitamin-K oral...
BACKGROUND: Age seemed to affect the interaction between coumarins and genotype in the acenocoumarol...
BACKGROUND: Observational evidence suggests that the use of a genotype-guided dosing algorithm may i...
Essentials Prospective studies of pharmacogenetic-guided (PG) coumarin dosing produced varying resul...
Journal Article; Research Support, Non-U.S. Gov't;There is a strong association between genetic poly...
AIM: To evaluate the performance of the European Pharmacogenetics of Anticoagulant Therapy (EU-PACT)...
<div><p>There is a strong association between genetic polymorphisms and the acenocoumarol dosage req...
BACKGROUND: The large variability in dose requirement of vitamin K antagonists is well known. For wa...
Background It has not been investigated how much the use of clinical factors in a dosing algorithm i...
Introduction: A large proportion of the coumarin dose variability is explained by environmental fact...
Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed...
Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed...
Appropriate dosing of coumarins is difficult to establish, due to significant inter-individual varia...
INTRODUCTION: A large proportion of the coumarin dose variability is explained by environmental fact...
<div><p>Appropriate dosing of coumarins is difficult to establish, due to significant inter-individu...
Abstract Background Hemorrhagic events are frequent in patients on treatment with antivitamin-K oral...
BACKGROUND: Age seemed to affect the interaction between coumarins and genotype in the acenocoumarol...
BACKGROUND: Observational evidence suggests that the use of a genotype-guided dosing algorithm may i...
Essentials Prospective studies of pharmacogenetic-guided (PG) coumarin dosing produced varying resul...
Journal Article; Research Support, Non-U.S. Gov't;There is a strong association between genetic poly...
AIM: To evaluate the performance of the European Pharmacogenetics of Anticoagulant Therapy (EU-PACT)...
<div><p>There is a strong association between genetic polymorphisms and the acenocoumarol dosage req...
BACKGROUND: The large variability in dose requirement of vitamin K antagonists is well known. For wa...
Background It has not been investigated how much the use of clinical factors in a dosing algorithm i...
Introduction: A large proportion of the coumarin dose variability is explained by environmental fact...
Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed...
Essentials A pediatric pharmacogenetic dosing algorithm for acenocoumarol has not yet been developed...
Appropriate dosing of coumarins is difficult to establish, due to significant inter-individual varia...
INTRODUCTION: A large proportion of the coumarin dose variability is explained by environmental fact...
<div><p>Appropriate dosing of coumarins is difficult to establish, due to significant inter-individu...
Abstract Background Hemorrhagic events are frequent in patients on treatment with antivitamin-K oral...