The value of Entrepreneurial, Innovative and Sustainable (EIS) ecosystems has seen increasing recognition from policymakers and researchers alike. Like-minded policymakers employing New Public Management (NPM) understand that the intricate links between diverse EIS stakeholders play a vital role in ad-vancing sources of local transformation – entrepreneurship and innovation – to enhance citizen wellbeing (e.g. happiness, trust, safety and satisfaction). A persis-tent challenge to both academic and policy research, however, is uncovering how and why EIS ecosystem stakeholders do or do not interact and influence one an-other to produce intended outcomes. In this chapter, we propose, and explain a novel framework for analysing and assessing EI...