Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We studied these effects on dendritic cell (DC) and T-cell subsets in 36 melanoma sentinel lymph node (SLN) from 28 stage I-III melanoma patients and determined their clinical significance. Four conventional DC subsets, plasmacytoid DCs, and CD4(+), CD8(+), and regulatory T cells (Tregs), were analyzed by flow cytometry. We correlated these data to clinical parameters and determined their effect on local and distant melanoma recurrence, with a median follow-up of 75 months. In stage I and II melanoma, increased Breslow thickness (i.e., invasion depth of the primary melanoma) was associated with progressive suppression of skin-derived migratory ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
International audienceThe advent of immune checkpoint blockers and targeted therapies has changed th...
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We...
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We...
Melanoma is an immunogenic tumor whose relationship with immune cells resident in the microenvironme...
The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concern...
Escape from immune surveillance is critical for tumor progression in metastatic melanoma. We assesse...
© Lippincott Williams & WilkinsNodal deposits of melanoma may present many years after resection of ...
Background Immunotherapy with checkpoint inhibitors has shown impressive results in patients with me...
PURPOSE: The success of immunotherapy with dendritic cells (DC) to treat cancer is dependent on effe...
Background: Immune markers in the peripheral blood of melanoma patients provide useful information f...
Melanoma has a propensity for lymphatogenous metastasis. Improved understanding of the sentinel lymp...
Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the firs...
Abstract Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
International audienceThe advent of immune checkpoint blockers and targeted therapies has changed th...
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We...
Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We...
Melanoma is an immunogenic tumor whose relationship with immune cells resident in the microenvironme...
The clinical relevance of dendritic cells (DCs) at the tumor site remains a matter of debate concern...
Escape from immune surveillance is critical for tumor progression in metastatic melanoma. We assesse...
© Lippincott Williams & WilkinsNodal deposits of melanoma may present many years after resection of ...
Background Immunotherapy with checkpoint inhibitors has shown impressive results in patients with me...
PURPOSE: The success of immunotherapy with dendritic cells (DC) to treat cancer is dependent on effe...
Background: Immune markers in the peripheral blood of melanoma patients provide useful information f...
Melanoma has a propensity for lymphatogenous metastasis. Improved understanding of the sentinel lymp...
Sentinel lymph nodes set the stance of the immune system to a localized tumor and are often the firs...
Abstract Purpose: In a previous immunohistochemical study of dendritic cells (DC) in sentinel lymph ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
Melanoma is an immunogenic neoplasm infiltrated by T cells, although these adaptive T cells usually ...
International audienceThe advent of immune checkpoint blockers and targeted therapies has changed th...