Structural Neuroimaging and Neuropsychologic Signatures in Children With Vertically Acquired HIV
- Paul, Robert
- Prasitsuebsai, Wasana
- Jahanshad, Neda
- Puthanakit, Thanyawee
- Thompson, Paul
- Aurpibul, Linda
- Hansudewechakul, Rawiwan
- Kosalaraksa, Pope
- Kanjanavanit, Suparat
- Ngampiyaskul, Chaiwat
- Luesomboon, Wicharn
- Lerdlum, Sukalaya
- Pothisri, Mantana
- Visrutaratna, Pannee
- Valcour, Victor
- Nir, Talia M.
- Saremi, Arvin
- Kerr, Stephen
- Ananworanich, Jintanat
DOIAbstract
BACKGROUND: Children with vertically acquired HIV exhibit persistent cognitive impairments, yet the corresponding neuroimaging signature of vertical infection remains unclear. METHODS: Fifty healthy control children and 51 vertically infected children were included in the study. The HIV-infected group consisted of survivors who had not received antiretroviral therapy at birth. The HIV-infected group averaged 11.4 (2.5) years of age, with a median CD4 count of 683 cells/mm(3). Most (71%) of the HIV-infected children were on antiretroviral therapy for a median of 34 months (range: 33-42) with HIV RNA <40 copies/mL in 89% of the sample. The HIV-uninfected group averaged 10.6 (2.6) years of age. Magnetic resonance imaging was acquired to determ...
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