Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease
- Allegretti, Yessica Lorena
- Bondar, Constanza María
- Guzmán, Luciana
- Cueto Rua, Eduardo
- Chopita, Nestor
- Fuertes, Mercedes Beatriz
- Zwirner, Norberto Walter
- Chirdo, Fernando Gabriel
DOIAbstract
The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen presentation. MICA/B are up-regulated by different stress conditions such as heat-shock, oxidative stress, neoplasic transformation and viral infection. Particularly, MICA/B are expressed in enterocytes where they can mediate enterocyte apoptosis when recognised by the activating NKG2D receptor present on intraepithelial lymphocytes. This mechanism was suggested to play a major pathogenic role in active celiac disease (CD). Due to the importance of MICA/B in CD pathogenesis we studied their expression in duodenal tissue from CD patients. By immunofluorescence confocal microscopy and flow cytometry we est...
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