Add to ORKGThioredoxin-1 (Trx1) protects the heart from ischemia/reperfusion (I/R) injury. Given that the age at which the first episode of coronary disease takes place has considerably decreased, life at middle-aged (MA) emerges as a new field of study. The aim was determine whether infarct size, Trx1 expression and activity, Akt and GSK-3β were altered in young (Y) and MA mice overexpressing cardiac Trx1, and in a dominant negative (DN-Trx1) mutant of Trx1. Langendorff-perfused hearts were subjected to 30 minutes of ischemia and 120 minutes of reperfusion (R). We used 3 and 12 month-old male of wild type (WT), Trx1, and DN-Trx1. Trx1 overexpression reduced infarct size in young mice (WT-Y: 46.8±4.1% vs. Trx1-Y: 27.6±3.5%, p < 0.05). Trx1 activity wa...
In our experiments, we have been used isolated working mouse hearts to study the role of redox-signa...
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) a...
Oxidative stress occurs with disturbed blood flow, inflammation and cardiovascular disease (CVD), ye...
Thioredoxin-1 (Trx-1) is part of an antioxidant system that maintains the cell redox homeostasis but...
Thioredoxin-1 maintains the cellular redox status and decreases the infarct size in ischemia/reperfu...
Sepsis-induced myocardial dysfunction is associated with increased oxidative stress and mitochondria...
Thioredoxin is one of the most important cellular antioxidant systems known to date, and is responsi...
Oxidative stress plays a critical role in the pathophysiology of cardiac failure, including the modu...
The age-related loss of anti-oxidant defense reduces recovery from myocardial ischemia/reperfusion i...
Ischemic postconditioning (PostC) reduces infarct size in healthy experimental models. However, if p...
Abstract Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can ...
BACKGROUND: Excessive formation of reactive oxygen species contributes to tissue injury and function...
BACKGROUND: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal ...
Background-—Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal ...
Background: Oxidative stress due to reactive oxygen species (ROS) production is a key factor in the ...
In our experiments, we have been used isolated working mouse hearts to study the role of redox-signa...
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) a...
Oxidative stress occurs with disturbed blood flow, inflammation and cardiovascular disease (CVD), ye...
Thioredoxin-1 (Trx-1) is part of an antioxidant system that maintains the cell redox homeostasis but...
Thioredoxin-1 maintains the cellular redox status and decreases the infarct size in ischemia/reperfu...
Sepsis-induced myocardial dysfunction is associated with increased oxidative stress and mitochondria...
Thioredoxin is one of the most important cellular antioxidant systems known to date, and is responsi...
Oxidative stress plays a critical role in the pathophysiology of cardiac failure, including the modu...
The age-related loss of anti-oxidant defense reduces recovery from myocardial ischemia/reperfusion i...
Ischemic postconditioning (PostC) reduces infarct size in healthy experimental models. However, if p...
Abstract Growing evidence suggests that redox‐sensitive proteins including glutaredoxins (Grxs) can ...
BACKGROUND: Excessive formation of reactive oxygen species contributes to tissue injury and function...
BACKGROUND: Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal ...
Background-—Ubiquitous deletion of thioredoxin reductase 2 (Txnrd2) in mice is embryonically lethal ...
Background: Oxidative stress due to reactive oxygen species (ROS) production is a key factor in the ...
In our experiments, we have been used isolated working mouse hearts to study the role of redox-signa...
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) a...
Oxidative stress occurs with disturbed blood flow, inflammation and cardiovascular disease (CVD), ye...