Biased immunoglobulin heavy variable (IGHV) gene usage and distinctive B-cell receptor (BCR) features have been reported in chronic lymphocytic leukaemia (CLL), which may reflect clonal selection by antigens during disease development. Furthermore, the IGHV gene mutation status distinguishes two clinical entities of CLL, where patients with unmutated IGHV genes have an inferior prognosis compared to those with mutated IGHV genes. Recently, one subgroup of CLL patients expressing the IGHV3-21 gene was found to display highly similar immunoglobulin (IG) gene features, even within the heavy chain complementarity-determining region 3 (HCDR3). Patients in this subgroup typically had a poor prognosis. In paper I, we aimed to identify further subg...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is asso...
Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can d...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
The mutational status of the immunoglobulin heavy-chain variable region (IGHV) genes utilized by chr...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
We sought to investigate if B cell receptor immunoglobulin (BcR IG) stereotypy is associated with pa...
B-cell chronic lymphocytic leukemia (CLL) patients display leukemic clones bearing either germline o...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is asso...
Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can d...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
A fraction of chronic lymphocytic leukaemia (CLL) cases carry highly homologous B-cell receptors (BC...
The mutational status of the immunoglobulin heavy-chain variable region (IGHV) genes utilized by chr...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an impo...
We sought to investigate if B cell receptor immunoglobulin (BcR IG) stereotypy is associated with pa...
B-cell chronic lymphocytic leukemia (CLL) patients display leukemic clones bearing either germline o...
Recognition of biased immunoglobulin variable (IgV) gene usage in B-cell chronic lymphocytic leukemi...
Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is asso...
Recent studies have shown that the somatic mutation status of the immunoglobulin (Ig) VH genes can d...