The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease

It is a challenge to differentiate between HIV-associated neurocognitive disorders (HAND) and other types of neurocognitive disease in the ageing HIV-infected population. Here we describe a 63 year old HIV-infected woman who had a history, neuropsychological test result, and PET examination consistent with characteristic Alzheimer's disease (AD). The cerebrospinal fluid (CSF) biomarker profile was analogous to the profile typically found in AD in HIV-negative patients with increased t-tau and p-tau, a decreased level of A beta 42 and normal levels of CSF neurofilament light protein and sAPP alpha and sAPP beta, distinctly different from findings in HIV-associated dementia (HAD). Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD.<p>Swedish Research Council K2011-58P-20931-01-4 K2010-63P-21562-01-4 K2011-61X-20401-05-6 2013-2546 K2013-61X-14002-13-5; Sahlgrenska University Hospital ALF-GBG 430271 ALFGBG 441051 ALFGBG 139671