Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- Mitchell, Jonathan S.
- Li, Ni
- Weinhold, Niels
- Försti, Asta
- Ali, Mina
- van Duin, Mark
- Thorleifsson, Gudmar
- Johnson, David C.
- Chen, Bowang
- Halvarsson, Britt-Marie
- Gudbjartsson, Daniel F.
- Kuiper, Rowan
- Stephens, Owen W.
- Bertsch, Uta
- Broderick, Peter
- Campo, Chiara
- Einsele, Hermann
- Gregory, Walter A.
- Gullberg, Urban
- Henrion, Marc
- Hillengass, Jens
- Hoffmann, Per
- Jackson, Graham H.
- Johnsson, Ellinor
- Jöud, Magnus
- Kristinsson, Sigurjdur Y.
- Lenhoff, Stig
- Lenive, Oleg
- Mellqvist, Ulf-Henrik
- Migliorini, Gabriele
- Nahi, Hareth
- Nelander, Sven
- Nickel, Jolanta
- Nöthen, Markus M.
- Rafnar, Thorunn
- Ross, Fiona M.
- da Silva Filho, Miguel Inacio
- Swaminathan, Bhairavi
- Thomsen, Hauke
- Turesson, Ingemar
- Vangsted, Annette
- Vogel, Ulla
- Waage, Anders
- Walker, Brian A.
- Wihlborg, Anna-Karin
- Broyl, Annemiek
- Davies, Faith E.
- Thorsteinsdottir, Unnur
- Langer, Christian
- Hansson, Markus
- Kaiser, Martin
- Sonneveld, Pieter
- Stefansson, Kari
- Morgan, Gareth J.
- Goldschmidt, Hartmut
- Hemminki, Kari
- Nilsson, Björn
- Houlston, Richard S.
DOIAbstract
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs606...
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