Models explaining results on the genetic interaction of mutants with defects in the active site and proofreading of DNA polymerase ε

<p><b>Copyright information:</b></p><p>Taken from "Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations"</p><p>BMC Biology 2004;2():11-11.</p><p>Published online 26 May 2004</p><p>PMCID:PMC434536.</p><p>Copyright © 2004 Pavlov et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</p> Dissociation-proofreading. The newly synthesized DNA is in red. 'M' stands for incorrectly inserted nucleotide. DNA polymerase is drawn as octagonal oval; an exonuclease is drawn as rectangle. Three distinct roles of Pol ε in replication