Comparison of anti-Aβ titers of Aβ vaccinated APP and nontransgenic mice after acid dissociation of Aβ and anti-Aβ antibody

<p><b>Copyright information:</b></p><p>Taken from "Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice"</p><p>BMC Neuroscience 2004;5():21-21.</p><p>Published online 8 Jun 2004</p><p>PMCID:PMC442125.</p><p>Copyright © 2004 Li et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.</p> Results are from sera obtained 14 days after the fourth vaccination. All samples were incubated at pH 2.5, centrifuged through 10,000 MW filters and neutralized before ELISA assay. So the effects of genotype could be directly compared in the three vaccine conditions, the nontransgenic titer value for each vaccine group was set to 100%. Data presented are mean ± sem. * P < 0.05 compared to APP mice given the same vaccine. Sample size is 5–6 per group