Prokaryote and eukaryote genomes are distinguished by distinct patterns of codon pair usage

<p><b>Copyright information:</b></p><p>Taken from "tRNA properties help shape codon pair preferences in open reading frames"</p><p>Nucleic Acids Research 2006;34(3):1015-1027.</p><p>Published online 9 Feb 2006</p><p>PMCID:PMC1363775.</p><p>© The Author 2006. Published by Oxford University Press. All rights reserved</p> For all genomes tested, the codon pair residual values ( − ) were tabulated, ordered by expected frequency, and separated into 10 bins. For each bin, the mean residual value was calculated. () Mean residual values plotted for each of the 10 bins (0–10% bin is the left-most bar in each group of ten). () Residuals were further smoothed into two equal bins before averaging, one bin containing the expected 50% least abundant codon pairs (black bars), the other the expected 50% most abundant codon pairs (white bars)