Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys-4

<p><b>Copyright information:</b></p><p>Taken from "Isoflurane depresses hippocampal CA1 glutamate nerve terminals without inhibiting fiber volleys"</p><p>BMC Neuroscience 2006;7():5-5.</p><p>Published online 12 Jan 2006</p><p>PMCID:PMC1369004.</p><p>Copyright © 2006 Winegar and MacIver; licensee BioMed Central Ltd.</p>epresentative whole-cell perforated patch in the pyramidal cell body layer of the hippocampal CA1 region. 100 ms voltage pulses to -30 mV were applied at 10 s intervals to elicit spikes (V= -70 mV). Currents in green show four spikes recorded after a 15 min exposure to 60 nM TTX. At right are overlays of spike currents recorded before and after a 10 min exposure to 350 μM isoflurane (1 MAC). The blue traces were recorded after exposure to isoflurane