Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector-2

<p><b>Copyright information:</b></p><p>Taken from "Neuroprotection from NMDA excitotoxic lesion by Cu/Zn superoxide dismutase gene delivery to the postnatal rat brain by a modular protein vector"</p><p>BMC Neuroscience 2006;7():35-35.</p><p>Published online 25 Apr 2006</p><p>PMCID:PMC1462999.</p><p>Copyright © 2006 Peluffo et al; licensee BioMed Central Ltd.</p>ity (A, Or: stratum oriens; Py; stratum pyramidalis; Ra: stratum radiatum). After NMDA injection, an increased immunorectivity was detected (B). However, animals overexpressing Cu/Zn SOD showed reduction in nitrotyrosine immunoreactivity (C), while animals overexpressing GFP showed a less pronounced reduction (D). Quantitative analysis confirmed these observations whereby, only animals overexpressing Cu/Zn SOD showed a significant (p < 0.05) decrease in nitrotyrosine immunoreactivity (E)