DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-0

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p> asterisks. The flanking palindrome areas of CDEIII are indicated by lighter arrows. Below each of the wild type sequences, the different mutant bases tested for each wild type base position are shown. Beneath each mutant, the bold vertical line indicates it's relative log(loss) rate, of magnitude indicated by the log scale shown. These data are recreated from Hegemann et al [7] Figure 3. The inset depicts a model of the yeast centromere showing the modified nucleosome formed by wrapping the CDEI site into close proximity to CDEIII. Also shown are their associated protein complexes that along with additional binding proteins form the kinetochore, which bind the spindle microtubule [2]