CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways-3

<p><b>Copyright information:</b></p><p>Taken from "CD40L induces multidrug resistance to apoptosis in breast carcinoma and lymphoma cells through caspase independent and dependent pathways"</p><p>BMC Cancer 2006;6():75-75.</p><p>Published online 18 Mar 2006</p><p>PMCID:PMC1435764.</p><p>Copyright © 2006 Voorzanger-Rousselot et al; licensee BioMed Central Ltd.</p>); or pre-incubated 24 hours with cell permeable inhibitors of caspase-9-like activity (z-LEHD) or caspase-8-like activity (z-IETD) or caspase-3-like activity (z-DEVD) and then 24 hours with drugs (C2 or C6 or DOX). Cells were finally tested for apoptosis using the TUNEL assay as indicated in Materials and Methods. *Apoptosis was significantly decreased (Student t test, p < 0.05) upon co-culture with caspases inhibitors as compared to no caspases inhibitors