Application of a sensitive collection heuristic for very large protein families: Evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases-2

<p><b>Copyright information:</b></p><p>Taken from "Application of a sensitive collection heuristic for very large protein families: Evolutionary relationship between adipose triglyceride lipase (ATGL) and classic mammalian lipases"</p><p>BMC Bioinformatics 2006;7():164-164.</p><p>Published online 21 Mar 2006</p><p>PMCID:PMC1435942.</p><p>Copyright © 2006 Schneider et al; licensee BioMed Central Ltd.</p> segments that were found with pancreatic lipase as seed for the FAMILYSEARCHER procedure, while the lower part contains the results of the patatin family-search. The starting sequences for the iterative procedures each have an asterix between parentheses (*) after the accession number. Important spots of the tree are marked by a bracket that is followed by a short description. Here, the classic lipases in the alignment are hepatic lipase (AAA59221), lipoprotein lipase (AAP35372), endothelial lipase (NP_006024) and pancreatic lipase (P16233). The bottom of the tree also contains three type A2 cytosolic phospholipases. Besides patatin (1OXW, [13]), this is the second type of protein from the pooled results that has been shown to function via a catalytic dyad (1CJY, [14])