Clustering analysis of TS dependent cytotoxicity in HCT-C18 (TS+) cells (Lane 1) treated with 10 μM 5-FU for 4 hrs (Lane 2) and 24 hrs (Lane 3) based on the expression profiles generated from steady state total mRNAs via One-way ANOVA analysis with p 0

Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.

Alessio Ligabue
Gaetano Marverti
Ursula Liebl
Hannu Myllykallio

BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human...

Prediction of chemosensitivity to 5-fluorouracil and its derivates in patients treated with chemotherapy for colorectal cancer

Zimovjanová, Martina

January 2009

Aim: 5-Fluorouracil (5-FU) is the most commonly used anticancer drug for colorectal cancer (CRC). In...

Gene expression responses reflecting 5-FU-induced toxicity:Comparison between patient colon tissue and 3D human colon organoids

Rodrigues, Daniela
van Kampen, Roel
van Bodegraven, Ad A
Kleinjans, Jos C S
Jennen, Danyel G J
de Kok, Theo M

December 2022

Capecitabine is a chemotherapeutic drug that is widely used as a monotherapy option in advanced canc...

Clustering analysis of predictive marker genes for TS independent cytotoxicity in HCT-C18 (TS-) cells (Lane 1) treated with 10 μM 5-FU for 4 hrs (Lane 2) and 24 hrs (Lane 3) via One-way ANOVA analysis with p 0

Yaguang Xi (48632)
Go Nakajima (62480)
John C Schmitz (62481)
Edward Chu (62482)
Jingfang Ju (48634)

December 2011

Copyright information:Taken from "Multi-level gene expression profiles affected by ...

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer

Chu Edward
Schmitz John C
Nakajima Go
Xi Yaguang
Ju Jingfang

April 2006

Abstract Background Thymidylate synthase (TS) is a critical target for cancer chemotherapy and is on...

Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.

Kentaro Wakasa
Rumi Kawabata
Seiki Nakao
Hiroyoshi Hattori
Kenichi Taguchi
Junji Uchida
Takeharu Yamanaka
Yoshihiko Maehara
Masakazu Fukushima
Shinya Oda

Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in ...

Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells

Kentaro Wakasa (725067)
Rumi Kawabata (725068)
Seiki Nakao (725069)
Hiroyoshi Hattori (58883)
Kenichi Taguchi (700165)
Junji Uchida (488633)
Takeharu Yamanaka (72566)
Yoshihiko Maehara (58872)
Masakazu Fukushima (725070)
Shinya Oda (58871)

April 2015

<div>Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are s...

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols

De Angelis, Paula M
Kravik, Katherine L
Tunheim, Siv H
Haug, Terje
Reichelt, Wenche H

January 2004

Background Established colorectal cancer cell lines subjected to different 5-fluorou...

A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.

Niedzwiecki, Donna
Hasson, Rian M
Lenz, Heinz-Josef
Ye, Cynthia
Redston, Mark
Ogino, Shuji
Fuchs, Charles S
Compton, Carolyn C
Mayer, Robert J
Goldberg, Richard M
Colacchio, Thomas A
Saltz, Leonard B
Warren, Robert S
Bertagnolli, Monica M

January 2017

PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemothera...

A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.

Niedzwiecki, Donna
Hasson, Rian M
Lenz, Heinz-Josef
Ye, Cynthia
Redston, Mark
Ogino, Shuji
Fuchs, Charles S
Compton, Carolyn C
Mayer, Robert J
Goldberg, Richard M
Colacchio, Thomas A
Saltz, Leonard B
Warren, Robert S
Bertagnolli, Monica M

January 2017

PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemothera...

Influence of thymidylate synthase expression on survival in patients with colorectal cancer

Kinjal K Gajjar
Toral P Kobawala
Trupti I Trivedi
Hemangini H Vora
Nandita R Ghosh

January 2017

Background: Thymidylate synthase (TS) plays a critical role in nucleotide metabolism and is an impor...

MOLECULAR PHARMACOLOGY, 43:527-533 Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and lnter1eron-y

Edward Chu
David M. Koeller
Patrick G. Johnston
Sydelle Zinn
Carmen J. Allegra

January 1992

The effects of fluorouracil (5-FU) and interferon--1 ’ (IFN--y) on the regulation of thymidylate syn...

Could a variant structural form of thymidylate synthase gene of metastatic colorectal cancer patients be related with the poor response to 5 Fu treatment?

CALASCIBETTA, Anna
GULOTTA, Gaspare
DIANA, Giuseppe
GUERCIO, Giovanni
SANGUEDOLCE, Giorgio
SANGUEDOLCE, Rosario

January 2008

Background: Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of 5-...

Could a variant structural form of thymidylate synthase gene of metastatic colorectal cancer patients be related with the poor response to 5 Fu treatment?

Calascibetta, A.
Gulotta, G.
Diana, G.
Guercio, G.
Sanguedolce, G.
Sanguedolce, R.

January 2008

Background: Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of 5-...

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

Backus, H H
Pinedo, H M
Wouters, D
Kuiper, C M
Jansen, G
van Groeningen, C J
Peters, G J

January 2000

Thymidylate synthase (TS) is an important target for chemotherapy and can be inhibited by 5-fluorour...

Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.

Alessio Ligabue
Gaetano Marverti
Ursula Liebl
Hannu Myllykallio

BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human...

Prediction of chemosensitivity to 5-fluorouracil and its derivates in patients treated with chemotherapy for colorectal cancer

Zimovjanová, Martina

January 2009

Aim: 5-Fluorouracil (5-FU) is the most commonly used anticancer drug for colorectal cancer (CRC). In...

Gene expression responses reflecting 5-FU-induced toxicity:Comparison between patient colon tissue and 3D human colon organoids

Rodrigues, Daniela
van Kampen, Roel
van Bodegraven, Ad A
Kleinjans, Jos C S
Jennen, Danyel G J
de Kok, Theo M

December 2022

Capecitabine is a chemotherapeutic drug that is widely used as a monotherapy option in advanced canc...

Clustering analysis of predictive marker genes for TS independent cytotoxicity in HCT-C18 (TS-) cells (Lane 1) treated with 10 μM 5-FU for 4 hrs (Lane 2) and 24 hrs (Lane 3) via One-way ANOVA analysis with p 0

Yaguang Xi (48632)
Go Nakajima (62480)
John C Schmitz (62481)
Edward Chu (62482)
Jingfang Ju (48634)

December 2011

Copyright information:Taken from "Multi-level gene expression profiles affected by ...

Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer

Chu Edward
Schmitz John C
Nakajima Go
Xi Yaguang
Ju Jingfang

April 2006

Abstract Background Thymidylate synthase (TS) is a critical target for cancer chemotherapy and is on...

Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.

Kentaro Wakasa
Rumi Kawabata
Seiki Nakao
Hiroyoshi Hattori
Kenichi Taguchi
Junji Uchida
Takeharu Yamanaka
Yoshihiko Maehara
Masakazu Fukushima
Shinya Oda

Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in ...

Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells

Kentaro Wakasa (725067)
Rumi Kawabata (725068)
Seiki Nakao (725069)
Hiroyoshi Hattori (58883)
Kenichi Taguchi (700165)
Junji Uchida (488633)
Takeharu Yamanaka (72566)
Yoshihiko Maehara (58872)
Masakazu Fukushima (725070)
Shinya Oda (58871)

April 2015

<div>Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are s...

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols

De Angelis, Paula M
Kravik, Katherine L
Tunheim, Siv H
Haug, Terje
Reichelt, Wenche H

January 2004

Background Established colorectal cancer cell lines subjected to different 5-fluorou...

A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.

Niedzwiecki, Donna
Hasson, Rian M
Lenz, Heinz-Josef
Ye, Cynthia
Redston, Mark
Ogino, Shuji
Fuchs, Charles S
Compton, Carolyn C
Mayer, Robert J
Goldberg, Richard M
Colacchio, Thomas A
Saltz, Leonard B
Warren, Robert S
Bertagnolli, Monica M

January 2017

PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemothera...

A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.

Niedzwiecki, Donna
Hasson, Rian M
Lenz, Heinz-Josef
Ye, Cynthia
Redston, Mark
Ogino, Shuji
Fuchs, Charles S
Compton, Carolyn C
Mayer, Robert J
Goldberg, Richard M
Colacchio, Thomas A
Saltz, Leonard B
Warren, Robert S
Bertagnolli, Monica M

January 2017

PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemothera...

Influence of thymidylate synthase expression on survival in patients with colorectal cancer

Kinjal K Gajjar
Toral P Kobawala
Trupti I Trivedi
Hemangini H Vora
Nandita R Ghosh

January 2017

Background: Thymidylate synthase (TS) plays a critical role in nucleotide metabolism and is an impor...

MOLECULAR PHARMACOLOGY, 43:527-533 Regulation of Thymidylate Synthase in Human Colon Cancer Cells Treated with 5-Fluorouracil and lnter1eron-y

Edward Chu
David M. Koeller
Patrick G. Johnston
Sydelle Zinn
Carmen J. Allegra

January 1992

The effects of fluorouracil (5-FU) and interferon--1 ’ (IFN--y) on the regulation of thymidylate syn...

Could a variant structural form of thymidylate synthase gene of metastatic colorectal cancer patients be related with the poor response to 5 Fu treatment?

CALASCIBETTA, Anna
GULOTTA, Gaspare
DIANA, Giuseppe
GUERCIO, Giovanni
SANGUEDOLCE, Giorgio
SANGUEDOLCE, Rosario

January 2008

Background: Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of 5-...

Could a variant structural form of thymidylate synthase gene of metastatic colorectal cancer patients be related with the poor response to 5 Fu treatment?

Calascibetta, A.
Gulotta, G.
Diana, G.
Guercio, G.
Sanguedolce, G.
Sanguedolce, R.

January 2008

Background: Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and is the target of 5-...

Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates

Backus, H H
Pinedo, H M
Wouters, D
Kuiper, C M
Jansen, G
van Groeningen, C J
Peters, G J

January 2000

Thymidylate synthase (TS) is an important target for chemotherapy and can be inhibited by 5-fluorour...

Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.

Alessio Ligabue
Gaetano Marverti
Ursula Liebl
Hannu Myllykallio

BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human...

Prediction of chemosensitivity to 5-fluorouracil and its derivates in patients treated with chemotherapy for colorectal cancer

Zimovjanová, Martina

January 2009

Aim: 5-Fluorouracil (5-FU) is the most commonly used anticancer drug for colorectal cancer (CRC). In...

Gene expression responses reflecting 5-FU-induced toxicity:Comparison between patient colon tissue and 3D human colon organoids

Rodrigues, Daniela
van Kampen, Roel
van Bodegraven, Ad A
Kleinjans, Jos C S
Jennen, Danyel G J
de Kok, Theo M

December 2022

Capecitabine is a chemotherapeutic drug that is widely used as a monotherapy option in advanced canc...

Clustering analysis of TS dependent cytotoxicity in HCT-C18 (TS+) cells (Lane 1) treated with 10 μM 5-FU for 4 hrs (Lane 2) and 24 hrs (Lane 3) based on the expression profiles generated from steady state total mRNAs via One-way ANOVA analysis with p 0

Abstract

Extracted data

Clustering analysis of TS dependent cytotoxicity in HCT-C18 (TS+) cells (Lane 1) treated with 10 μM 5-FU for 4 hrs (Lane 2) and 24 hrs (Lane 3) based on the expression profiles generated from steady state total mRNAs via One-way ANOVA analysis with p 0

Abstract

Extracted data

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