Genetic organisation of the gene clusters of the closely related lantibiotics lacticin 3147 (A) and staphylococcin C55 (B)

<p><b>Copyright information:</b></p><p>Taken from "Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity"</p><p>http://www.biomedcentral.com/1471-2180/7/24</p><p>BMC Microbiology 2007;7():24-24.</p><p>Published online 2 Apr 2007</p><p>PMCID:PMC1858699.</p><p></p> C depicts a comparison of the amino acid sequence of the propeptide of one of the structural components of lacticin 3147 (LtnA1) and staphylococcin C55 (C55α). D depicts a comparison of the amino acid sequence of the propeptide of one of the structural components of lacticin 3147 (LtnA2) and staphylococcin C55 (C55β). Homologous amino acids are indicated in bold, differences are indicated in red. E and F indicates evolutionary divergence (measured in the number of substitution events) between the unmodified lantibiotic propeptides (E) LtnA1 and C55α and (F) LtnA2 and C55β. (G) Visualization of homology modeling of LtnA1 (gold) and C55α (purple)