Signalling pathways of inhibition by galectin-3 (gal-3) of vitamin D-stimulated osteocalcin production

<p><b>Copyright information:</b></p><p>Taken from "Extracellular localization of galectin-3 has a deleterious role in joint tissues"</p><p>http://arthritis-research.com/content/9/1/R20</p><p>Arthritis Research & Therapy 2007;9(1):R20-R20.</p><p>Published online 27 Feb 2007</p><p>PMCID:PMC1860078.</p><p></p> Osteoblasts were treated with 5 μg/ml of recombinant human gal-3 in the presence of vitamin Dand osteocalcin was determined. Inhibitor concentrations were: KT5720, 2 μM; KT5823, 2 μM; Genistein (Genist.), 1 μM; Taxifollin, 1 μM; wortmannin (Wortma.), 250 nM; PD98059, 10 μM; and SB202190, 2 μM. *versus the autologous control; = 5