HmtDB, a Human Mitochondrial Genomic Resource Based on Variability Studies Supporting Population Genetics and Biomedical Research-2

<p><b>Copyright information:</b></p><p>Taken from "HmtDB, a Human Mitochondrial Genomic Resource Based on Variability Studies Supporting Population Genetics and Biomedical Research"</p><p></p><p>BMC Bioinformatics 2005;6(Suppl 4):S4-S4.</p><p>Published online 1 Dec 2005</p><p>PMCID:PMC1866381.</p><p></p>program, three variability analyses are executed separately: nucleotide variability values for both the entire set of genomes and the continent-specific subsets are estimated through SiteVar program applied on real dataset (right hand side of the Work Flow) and on 100 simulated multialignments obtained through an automatic procedure for each continent-specific genomes dataset (in the middle of the Work Flow); aminoacid variability data (left hand side of the Work Flow) are produced by applying MitVarProt software to the 13 multialigned mitochondrial protein coding genes, automatically selected from the entire starting nucleotide multialignment and translated into aminoacid sequences through TRANSEQ program; the data produced through this three procedures are inserted in NT_VARIABILITY, NT_VARIABILITY_SIM and AA_VARIABILITY tables of the relational HmtDB structure respectively