Snapshot of the final configuration of simulation E, showing only the core subdomain III, the C-terminal, and the linker domain regions of the protein

<p><b>Copyright information:</b></p><p>Taken from "The open state of human topoisomerase I as probed by molecular dynamics simulation"</p><p></p><p>Nucleic Acids Research 2007;35(9):3032-3038.</p><p>Published online 16 Apr 2007</p><p>PMCID:PMC1888835.</p><p>© 2007 The Author(s)</p> Helices 8, 9 and 16 and the catalytic Arg590 are highlighted in the figure to evidentiate the hydrophobic interactions between the C-terminal portion of helix 8 and helix 16. The hinge residue Glu445 is also indicated by an arrow