Diagram indicating associations among genetic and environmental factors reduce and their interactions with intermediate phenotypes to yield distinct pathophenotypes

<p><b>Copyright information:</b></p><p>Taken from "Human disease classification in the postgenomic era: A complex systems approach to human pathobiology"</p><p>Molecular Systems Biology 2007;3():124-124.</p><p>Published online 10 Jul 2007</p><p>PMCID:PMC1948102.</p><p>Copyright © 2007, EMBO and Nature Publishing Group</p> The intermediate phenotypes determine, in part, variation in disease expression and clinical presentation among individuals with equivalent underlying genetic or environmental exposures that predispose to a disease state