The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish-5

<p><b>Copyright information:</b></p><p>Taken from "The evolutionary conservation of the core components necessary for the extrinsic apoptotic signaling pathway, in Medaka fish"</p><p>http://www.biomedcentral.com/1471-2164/8/141</p><p>BMC Genomics 2007;8():141-141.</p><p>Published online 1 Jun 2007</p><p>PMCID:PMC1903365.</p><p></p>tracellular region. The double line and the dotted line indicate the transmembrane region and the death domain (DD) within the cytoplasmic region, respectively. (B) Alignment of Medaka and human FADD. The bold and dotted lines under the sequence indicate the death effector domain (DED) and the DD, respectively. (C) Alignment of Medaka and human caspase-8 (CASP8). The two bold lines and a box indicate the DEDs and the protease domain, respectively. Asterisks represent the amino acids essential for catalytic activity. Identical and similar amino acids between Medaka and human in all alignments are indicated in black and shaded boxes, respectively