Since active sites residues are enriched in hinges, we performed a separate conservation check on hinge residues in the 94 Hinge Atlas proteins with CSA annotation

<p><b>Copyright information:</b></p><p>Taken from "Hinge Atlas: relating protein sequence to sites of structural flexibility"</p><p>http://www.biomedcentral.com/1471-2105/8/167</p><p>BMC Bioinformatics 2007;8():167-167.</p><p>Published online 22 May 2007</p><p>PMCID:PMC1913541.</p><p></p> We found that even in this set, the least conserved 1/5of amino acids in each protein tended to contain significantly more hinge residues. The fourth bin was sparse in hinge residues, but at a p-value of 0.043, the significance of this was marginal