Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression-0

<p><b>Copyright information:</b></p><p>Taken from "Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression"</p><p>http://www.biomedcentral.com/1471-2202/8/42</p><p>BMC Neuroscience 2007;8():42-42.</p><p>Published online 21 Jun 2007</p><p>PMCID:PMC1914080.</p><p></p>ted (ip) and mice were returned to the test chamber and monitored for another 60 min. A) and B): Time course of locomotor activity of WT mice and DAT-KD mice. Saline, 5 mg/kg, 10 mg/kg or 20 mg/kg cocaine was given at the time indicated by the arrows. Data shown are average distance traveled in 5 min. C) Total distance traveled in 60 minutes for wild type and DAT-KD mice during their habituation to the chambers before drug or saline injection. DAT-KD mice are significantly more active than wild type ice (***, p < 0.001, t-test). D) Total distance traveled in 30 min after the injection of saline or 5, 10, or 20 mg/kg cocaine with 6 – 8 mice in each group. Two-way ANOVA was performed. Cocaine significantly increased locomotor activities in both genotypes of mice (for drug effect, F= 22.38, p < 0.001) and had greater effect on DAT-KD mice than on the WT mice (for genotype, F= 19.57, p < 0.001). Error bars represent standard error of means. Post hoc Bonferroni tests versus saline: *, p < 0.05; **, p < 0.01; ***, p < 0.001. Comparing between the two genotypes, 5 mg/kg and 10 mg/kg cocaine had a greater effect on locomotor activity in the DAT-KD mice than in wild type mice (#, p < 0.01)