Tumor specific CTLs suppress the growth of autologous lung tumors in SCID mice

<p><b>Copyright information:</b></p><p>Taken from "Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model"</p><p>http://www.translational-medicine.com/content/5/1/29</p><p>Journal of Translational Medicine 2007;5():29-29.</p><p>Published online 25 Jun 2007</p><p>PMCID:PMC1933531.</p><p></p> SCID mice were injected with 5 × 10tumor cells intravenously. At day 5, after tumor foci were established in the lungs, mice were received either 5 × 10tumor specific or anti-flu CTLs (i.v. injection). At day 20 and 35, 6 mice from each group (I. control; II. tumor only; III. tumor plus flu-specific CTL or IV. tumor plus tumor-specific CTL were sacrificed and lung and liver were excised for further studies. . Lung weights; . Histology of normal lung; . Histology of lung from tumor bearing mice treated with anti-flu specific CTLs and . Histology of lung from tumor bearing mice treated with tumor specific anti-LT391-06 CTLs. Differences in lung weight between groups was evaluated by the student t-test: II versus III, < 0.95; II vs. IV, < 0.001; III vs. IV, P < 0.004