The anti-tumor effect of anti-LT391-06 CTLs against two HLA matched allogeneic tumor cells is antigen specific

<p><b>Copyright information:</b></p><p>Taken from "Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model"</p><p>http://www.translational-medicine.com/content/5/1/29</p><p>Journal of Translational Medicine 2007;5():29-29.</p><p>Published online 25 Jun 2007</p><p>PMCID:PMC1933531.</p><p></p> SCID mice in control groups (●) received a s.c. injection of 5 × 10tumor cells alone and mice in the treated groups (○) received a co-injection of 1 × 10anti-LT391-06 CTLs s.c. . Mice bearing A549 tumors, an allogeneic bronchioalveolar carcinoma cell line which does not express the LT391-06 Ag recognized by the tumor specific CTLs; . Mice bearing 936T, an allogeneic tumor cell line derived from a squamous lung carcinoma which does express this antigen. (= 5 mice/group