ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity-8

<p><b>Copyright information:</b></p><p>Taken from "ApoER2 expression increases Aβ production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of γ-secretase activity"</p><p>http://www.molecularneurodegeneration.com/content/2/1/14</p><p>Molecular Neurodegeneration 2007;2():14-14.</p><p>Published online 9 Jul 2007</p><p>PMCID:PMC1939850.</p><p></p>reated with DAPT 10 μM and protein association to lipid rafts was analyzed as in Figure 8. High sensitivity films were used for endogenous APP-CTFs detection. (), Lubrol-extracted proteins from lysates obtained in () were subjected to 10% SDS-PAGE. Blots were probed with anti-ApoER2, anti-APP and anti-actin or antibodies. Similar APP protein levels were detected in APP695-Myc and in APP695-Myc + ApoER2-HA transfected cells. Remnants of ApoER2 detection after stripping and reblot are indicated by an asterisk